This town was settled in 1824 by John P. Coles, one of Stephen F. Austin's original 300 Texas colonists. First called Coles' Settlement, the village name was changed in 1836 to commemorate the independence of Texas from Mexico. The town square was laid out for the Washington County courthouse, but Brenham won a heated county-seat election by two votes. See buildings associated with early Texas history on F.M. 50, a few miles north of Brenham.